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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11564 | HIV-1 inhibitor-3 | Others | |
HIV-1 inhibitor-3 is an HIV infection inhibitor. | |||
T11567 | HIV-1 integrase inhibitor 3 | Others | |
HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM). | |||
T9854 | HIV-1 inhibitor-6 | 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- | HIV Protease |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication. | |||
T11074 | Dolutegravir intermediate-1 | 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid | HIV Protease |
Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir intermediate. Dolutegravir is an integrase inhibitor develope... | |||
T7700 | Lersivirine | Lersivirine(UK 453061),UK-453061 | HIV Protease , Reverse Transcriptase |
Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy. | |||
T6418 | BMS-378806 | BMS378806,BMS-806 | gp120/CD4 , HIV Protease |
BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. | |||
T5949 | Dideoxyadenosine | ||
2',3'-Dideoxyadenosine is an inhibitor of HIV replication with antiretroviral activity and antiviral efficacy [1]. | |||
T10133 | 3'-Azido-3'-deoxy-5-methylcytidine | Antiviral , HIV Protease | |
3'-Azido-3'-deoxy-5-methylcytidine inhibits HIV-1 reverse transcriptase(EC50 = 0.06 μM) and is an effective inhibitor of xenotropic murine leukemia-related retrovirus (XMRV, CC50 = 43.5 μM). | |||
T0682 | Lamivudine | GR109714X,BCH-189 | HIV Protease , Reverse Transcriptase |
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. | |||
T14313 | Apricitabine | AVX754,SPD754 | HIV Protease , DNA/RNA Synthesis |
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β a... | |||
T2279 | Tizoxanide | Desacetyl-nitazoxanide,TIZ | Antiviral , HIV Protease , Antibacterial , Autophagy |
Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). | |||
T10603 | BRD-6929 | HIV Protease , HDAC | |
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin... | |||
T16791 | Rottlerin | Mallotoxin,NSC 56346,NSC 94525 | CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy |
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase... | |||
T24266 | KNI-1657 | ||
KNI-1657 is a potent and selective HIV-1 protease inhibitor (Anti-HIV-1 pNL4-3, EC50: 3 nM). KNI-1657 is a highly potent HIV-1 Protease Inhibitor against Lopinavir. | |||
T64131 | HIV-1 inhibitor-17 | ||
HIV-1 inhibitor-18 is a potent inhibitor of the HIV-1 capsid and is able to act on the HIV-1 NL4-3 strain (EC50: 2.57 μM). HIV-1 inhibitor-18 exhibits some cytotoxicity with an MT-4CC50 value of >8.55. | |||
T63687 | HIV-1 inhibitor-18 | ||
HIV-1 inhibitor-18 is a potent inhibitor of the HIV-1 capsid that acts against the HIV-1 NL4-3 strain (EC50: 5.14 μM) and exhibits some cytotoxicity (MT-4CC50>9.51). | |||
T72162 | HIV-1 integrase inhibitor 10 | ||
HIV-1 Integrase Inhibitor 10, an orally active allosteric integrase inhibitor (ALLINI), effectively inhibits the NLRepRluc virus's viral outgrowth in MT-2 cells, exhibiting EC50 values of 3-5 nM. This compound is utilize... | |||
T10986 | DDX3-IN-1 | Others | |
DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 of 50 and 36 μM for HIV and HCV, respectively. Antiviral activity. | |||
T60342 | HIV-1 inhibitor-47 | ||
HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhi... | |||
TNU0208 | 2’,3’-Dideoxy-3’-fluorocytidine | ||
Nucleoside Derivatives - 2’,3’-Dideoxy-nucleosides, Fluoro-modified nucleosides, 3’-Modified nucleosides; Drugs and Inhibitors; HIV-1 inhibitor |